References

Marvel SJ, Goldblatt B, MacPhail CM, Zersen KM The use of a novel nitric oxide wound dressing in acute traumatic wounds in dogs. Am J Vet Res.. 2024; 85:(9) https://doi.org/10.2460/ajvr.24.04.0124

Noxsano. Case studies. 2024. https://www.noxsano.com/case-study

Rodriguez-Diaz JM, Wallace ML, Emond SA, McNabney D, Hodges KM, Howerth EW Effect of hydrocolloidnitric oxide wound dressings on wound healing in dogs. Vet Surg.. 2024; 53:(8)1351-1365 https://doi.org/10.1111/vsu.14149

Wound care

Noxsano's innovative wound care solutions

02 April 2025
Comment
3 mins read
02 April 2025
Volume 30 · Issue 4
Figure 1. Grey hue of tissues following the use of the gel formulation. A) The wound at the time of presentation following clipping and lavage. B) The wound following placement of the activated gel formulation. C) The wound 2 days later, post lavage. Closure was performed at this visit, and healing was uncomplicated.
Figure 1. Grey hue of tissues following the use of the gel formulation. A) The wound at the time of presentation following clipping and lavage. B) The wound following placement of the activated gel formulation. C) The wound 2 days later, post lavage. Closure was performed at this visit, and healing was uncomplicated.

Abstract

Effective wound management is a cornerstone of veterinary care, aiming to accelerate healing, prevent infections and ensure the wellbeing of patients. Noxsano Animal Health has introduced ground-breaking products – Restore Wound Pads and Gels – that harness the power of nitric oxide to revolutionise wound treatment in veterinary medicine.

Injuries and surgical incisions in animals necessitate prompt and efficient healing to minimise stress and reduce the risk of infection. While human medicine offers advanced wound care therapies, their high costs often render them impractical for veterinary applications. This disparity highlights the need for affordable, yet effective solutions tailored to the unique requirements of veterinary patients.

Nitric oxide: a natural facilitator of healing

Nitric oxide is a naturally occurring molecule integral to various physiological processes, including wound healing. Its functions include:

  • Antimicrobial action: nitric oxide exhibits broad-spectrum antimicrobial properties, targeting bacteria, fungi, viruses and parasites, thereby preventing infections in the wound bed
  • Wound repair: nitric oxide regulates inflammation, promotes angiogenesis (formation of new blood vessels) and stimulates collagen synthesis, all crucial for effective wound healing.

    • These multifaceted functions position nitric oxide as a pivotal agent in the body's natural wound-healing cascade.

    Scientific validation of Noxsano's approach

    The following studies have confirmed the efficacy of nitric oxide-releasing wound dressings in promoting faster healing and reducing infection risks:

  • One clinical study demonstrated that dogs treated with hydrocolloid-nitric oxide dressings exhibited a 40% faster healing rate compared to standard wound dressings. The study found that nitric oxide dressings significantly reduced wound area and enhanced contraction, leading to faster granulation and tissue repair (Rodriguez-Diaz et al, 2024)
  • Another study assessed the efficacy of nitric oxide dressings in treating naturally occurring traumatic wounds. The study confirmed that nitric oxide dressings are safe, effective and suitable for managing a variety of wound types by secondary intention healing (Marvel et al, 2024).

    • These findings reinforce Noxsano's claim that their Restore wound pads and gels optimise healing conditions and improve clinical outcomes.

    Noxsano's innovative approach

    Recognising the therapeutic potential of nitric oxide, Noxsano developed a cost-effective method to deliver nitric oxide directly to the wound site. By using sodium nitrite, a common and inexpensive compound, Noxsano's products generate nitric oxide on activation with water. This on-demand production ensures a sustained release of biologically relevant levels of nitric oxide over several days, optimising the wound healing environment.

    Available products

    Restore wound pads

    These non-adherent pads are designed for extended use, up to 7 days, reducing the frequency of dressing changes. They conform easily to various wound shapes and sizes and contain hydrocolloidal components to manage exudate effectively.

    Restore wound gel

    Ideal for large wounds or areas with high mobility where secure bandaging is challenging, this hydrogel can be applied directly to the wound bed, maintaining a moist environment conducive to healing (Figure 1).

    Figure 1. Grey hue of tissues following the use of the gel formulation. A) The wound at the time of presentation following clipping and lavage. B) The wound following placement of the activated gel formulation. C) The wound 2 days later, post lavage. Closure was performed at this visit, and healing was uncomplicated.

    Case study

    A compelling case study by Dr Mandy Wallace (University of Georgia; Noxsano, 2024) highlights the efficacy of Restore wound pads in treating a complex, antibioticresistant wound in a 5-year-old English Bulldog (Figure 2). The dog's initial wound, likely caused by a dog attack, was closed surgically but dehisced as a result of infection with resistant Escherichia coli and owner noncompliance. Upon transitioning to Restore wound pads, the infection cleared within three applications, and healthy granulation tissue formed. Remarkably, no additional antibiotics were required post-treatment. The wound was successfully closed, and within two weeks, the patient had recovered fully.

    Figure 2. Case study stages with the use of Restore pad. A) Open wound, initial dehiscence. B) Closed wound after flap surgery. C) Wound 5 days post flap surgery. D) Cleaned wound with Restore pad. E) Wound after 3 Restore pad applications. F) Wound 2 weeks after surgery.

    Clinical and practical benefits

    Noxsano's Restore products offer several advantages over traditional wound dressings:

  • Faster healing: clinical studies validate accelerated tissue repair and reduced healing time
  • Lower risk of infection: nitric oxide's antimicrobial properties reduce microbial load, lowering the chances of wound-related complications z Cost effective: with prolonged wear time and fewer dressing changes, Noxsano's products offer an economical alternative to advanced human-grade wound care solutions
  • Easy application: The ability to activate and apply nitric oxide therapy in various wound conditions makes it a practical choice for veterinarians managing diverse cases.

    • Conclusions

    Noxsano's Restore Wound Pads and Gels represent a significant advancement in veterinary wound care, offering an affordable, effective and practical solution to enhance healing outcomes. By leveraging the natural properties of nitric oxide, these products provide veterinary professionals with innovative tools to improve patient care and recovery times.